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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
14.24
Human Site:
Y642
Identified Species:
22.38
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
Y642
R
T
L
L
E
E
E
Y
F
R
E
K
L
S
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
Y642
R
T
L
L
E
E
G
Y
F
R
E
K
L
S
D
Dog
Lupus familis
XP_531814
1283
145094
C616
C
V
F
Y
L
K
K
C
L
I
D
Q
E
L
L
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
Y641
R
T
L
L
E
G
G
Y
F
T
G
N
G
D
S
Rat
Rattus norvegicus
XP_002726765
1361
151628
Y644
R
T
L
L
E
G
G
Y
F
T
G
N
E
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
Y748
K
V
L
L
E
E
E
Y
F
K
E
N
Q
N
T
Frog
Xenopus laevis
NP_001089247
1340
149481
Y621
K
T
L
A
E
E
A
Y
F
E
K
D
F
Q
P
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
D641
L
K
V
L
A
E
E
D
Y
F
K
E
S
K
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
F537
K
A
L
G
Q
C
I
F
F
I
H
K
C
K
L
Honey Bee
Apis mellifera
XP_392346
1120
127429
P467
S
D
S
E
F
Q
W
P
T
G
L
Q
S
Y
L
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
R533
G
A
I
F
W
Y
L
R
D
S
L
I
D
V
D
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
D614
F
Y
I
G
Q
F
Q
D
D
R
H
S
S
R
F
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
P623
F
A
K
F
E
S
L
P
C
S
D
F
C
E
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
N615
G
I
I
Y
K
R
I
N
C
Q
P
S
S
A
Y
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
W589
G
L
L
Y
Y
L
K
W
L
K
L
D
K
N
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
93.3
0
N.A.
46.6
46.6
N.A.
N.A.
53.3
40
26.6
N.A.
20
0
6.6
6.6
P-Site Similarity:
100
N.A.
93.3
26.6
N.A.
46.6
46.6
N.A.
N.A.
73.3
53.3
53.3
N.A.
40
13.3
13.3
26.6
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
6.6
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
26.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
20
0
7
7
0
7
0
0
0
0
0
0
7
0
% A
% Cys:
7
0
0
0
0
7
0
7
14
0
0
0
14
0
0
% C
% Asp:
0
7
0
0
0
0
0
14
14
0
14
14
7
7
27
% D
% Glu:
0
0
0
7
47
34
20
0
0
7
20
7
14
7
0
% E
% Phe:
14
0
7
14
7
7
0
7
47
7
0
7
7
0
7
% F
% Gly:
20
0
0
14
0
14
20
0
0
7
14
0
7
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
14
0
0
0
0
% H
% Ile:
0
7
20
0
0
0
14
0
0
14
0
7
0
0
0
% I
% Lys:
20
7
7
0
7
7
14
0
0
14
14
20
7
14
0
% K
% Leu:
7
7
54
40
7
7
14
0
14
0
20
0
14
7
27
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
7
0
0
0
20
0
14
0
% N
% Pro:
0
0
0
0
0
0
0
14
0
0
7
0
0
0
7
% P
% Gln:
0
0
0
0
14
7
7
0
0
7
0
14
7
7
0
% Q
% Arg:
27
0
0
0
0
7
0
7
0
20
0
0
0
7
0
% R
% Ser:
7
0
7
0
0
7
0
0
0
14
0
14
27
14
14
% S
% Thr:
0
34
0
0
0
0
0
0
7
14
0
0
0
0
7
% T
% Val:
0
14
7
0
0
0
0
0
0
0
0
0
0
7
7
% V
% Trp:
0
0
0
0
7
0
7
7
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
20
7
7
0
40
7
0
0
0
0
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _